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Withdrawal symptoms from a prednisone taper (or any other taper from corticosteroids) may last anywhere from a few weeks to a year. A taper is a process in which a drug has been discontinued but the effectiveness of the drug is still maintained. A taper may involve taking the drug on a daily basis for one to three months or until it no longer has its anti-inflammatory effect on tissue. It is recommended that a steroid taper is completed no later than twelve months after the drug was given to determine its long-term efficacy. It may take several additional months to determine its long-term efficacy. After a taper has been started, the drug's anti-inflammatory effects will be restored as shown in this table. The use of corticosteroids can lead to significant long-term side effects, including: Increased pain and swelling in the body Liver and lymphoma Mouth sores and bleeding gums Testicular inflammation Increased risk of infection such as bacterial vaginosis and trachoma Reduced body weight Loss of hair or hair loss Nausea and vomiting In extreme cases a person may experience multiple side effects including: High blood pressure Pneumonia Kidney damage Numbness or tingling in or about the mouth Chest pain Seizures High or low blood pressure Risk of heart attack or sudden death In rare cases of a severe reaction (especially if the taper is not completed) the person might die. The American Society of Clinical Oncology has stated: "These risks do not necessarily indicate that corticosteroid use will have a long course. The risk must be assessed carefully, using the same precautions as with any medication with a known long-term risk of harmful side effect. These risks should be weighed against the benefits of the drug and the risks that are not immediately apparent." The Taper from corticosteroids is a complex process. It is one of the most important things that a patient should do to ensure that the drug will be effective and safe over the long haul. More detailed information about the taper can be found here: taper from corticosteroids Related Article: